The Role of Irisin, Copper and Zinc Levels on Insulin Resistance in Polycystic Ovary Syndrome

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Irisin is defined as a myocin released from skeletal muscle that protects individuals from metabolic diseases when exercised regularly. Zinc is thought to play an active role in the pathophysiology of PCOS in relation to insulin resistance. Copper has been stated to contribute to oxidative stress and insulin resistance in PCOS patients. The aim of this study was to evaluate the relationship between serum irisin, copper and zinc levels and insulin resistance in PCOS patients and control cases.

Methods: Our study consists of a patient group of 45 individuals diagnosed with PCOS and a healthy control group of 45 individuals. 2003 Rotterdam diagnostic criteria were used for the diagnosis of PCOS. Serum copper, zinc and irisin levels were measured and evaluated with regard to Body Mass Index and insulin resistance.

Results: Serum zinc and copper levels were found to be higher in PCOS patients compared to controls (p<0.05), however no statistically significant differences were found between the groups with regard to HOMA-IR and serum irisin levels.

Conclusions: It was evaluated that the data obtained from the patient group in this study may have been effected due to patients’ use of some medications like metformin, multivitamin supplements and oral contraceptives.