Archives of Current Medical Research 2021-05-29T15:13:09+00:00 Hasan Serdar Öztürk, MD, PhD. Professor of Medical Biochemistry Open Journal Systems <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">E-ISSN:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> 2717-9788</span></span></p> <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Please use Dergipark system for new submissions from link below.</span></span></strong></p> <p><a href=""><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"></span></span></strong></a></p> <p><span style="vertical-align: inherit;"><strong><span style="vertical-align: inherit;">Abstracting and Indexing:</span></strong><span style="vertical-align: inherit;"> EuroPub, Directory of Research Journal Indexing, Eurasian Scientific Journal Index, J-Gate, Scientific Indexing Services (SIS), CiteFactor, Asos İndeks, Türkiye Atıf Dizini, TurkMedline Google Scholar, Crossref</span></span></p> <p>Archives of Current Medical Research (ACMR) is an international, peer-reviewed, open-access scientific journal for publication of original medical, pre-clinical and clinical research, case reports, reviews and letters about all areas of medicine, dentistry and related medical disciplines. Each manuscript submitted to ACMR is primarily taken into editorial review. After that, the peer-review process begins for the selected manuscripts. ACMR uses double-blind review concealing author names from the reviewers and vice versa throughout the reviewing process. There are no submission or publication charges to submit your manuscript to ACMR. Manuscripts must be submitted electronically using the following link:</p> <p><strong>There are no submission or publication charges to submit your manuscript. </strong></p> <p>The authors have to submit their ORCID numbers during the submission.</p> <p>This journal provides instant open access to all content, bearing in mind the fact that presenting research free to the public supports a greater global exchange of knowledge.</p> <p>Articles "published" online are freely available to the public on the Internet.</p> <p><strong><em>The authors are responsible for the accuracy of the references. Key the references (double-spaced) at the end of the manuscript. EndNote users can access a direct download of the updated ACMR Publications style at </em></strong><a href=""><strong><em></em></strong></a></p> <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> <strong><a href=""><img src="" alt="" width="142" height="67" /></a> </strong> </span></span></span></span></p> Carboxyhemoglobin, Methemoglobin and Lactate Levels in Patients with Systemic Inflammatory Response Syndrome 2021-01-01T10:19:01+00:00 Selahattin Gürü Gültekin Kadı Begüm Öktem Mehmet Akif Karamercan <p><strong>Background:</strong> Systemic inflammatory response syndrome (SIRS) is a common, severe inflammatory condition. This condition forms the basis of the definitions of sepsis, severe sepsis, septic shock, and multiple organ failure syndromes. The diagnosis can be made earlier with arterial blood gas analysis, which can provide a lot of information within minutes. This study aimed to determine the value of carboxyhemoglobin (COHb), methemoglobin (metHb), and lactate levels in the prognosis and mortality of patients with SIRS.</p> <p><strong>Methods:</strong> Patients who met the SIRS criteria with the first vital signs and laboratory values and who had arterial blood gas analysis according to the clinician’s decision were included in the study. The demographic characteristics, prognosis and correlation of 1-month mortality rates of patients with baseline COHb, metHb and lactate levels were investigated.</p> <p><strong>Results:</strong> Among non-smoker patients, no significant difference was found between fCOHb values and age, gender, presence of infection, blood pressure, department of hospitalization, and 1-month mortality rates (p&gt;0.05). Also, the relationship between fCOHb values and length of stay in the hospital was not statistically significant (r = -0.013, p = 0.883). Among the patients included in the study; there was no significant difference in metHb values between age groups (p = 0.9941), gender (p = 0.6422), presence of infection (p = 0.1311), blood pressure (p = 0.7711), length of stay in hospital (p = 0.737), inpatient clinics (p = 0.6722) and 1-month mortality (p = 0.8752). Lactate values were found to be correlated with the 1-month mortality of the patients (p = 0.005). Lactate levels were significantly higher in patients who died within 1-month compared to those who survived.</p> <p><strong>Conclusions:</strong> In patients with SIRS, initial COHb and metHb values cannot be considered a predictor for prognosis and mortality. However, lactate values may be useful to predict SIRS mortality even during hospital admission.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Mean Platelet Volume and Red Cell Distribution Width Values in Patients with COVID-19 Admitted to Intensive Care Units or Wards from Emergency Department 2021-03-09T06:28:35+00:00 Mehmet Ali Ceyhan Miray Tümer Selahattin Gürü Gültekin Kadı Gültekin Günhan Demir <p><strong>Background:</strong> Mean platelet volume (MPV) and red cell distribution width (RDW) values are components of complete blood count (CBC) which is a routine, cheap and fast test used in the evaluation of patients admitted to the emergency department (ED). The present study aimed to investigate RDW and MPV values in patients with Novel Coronavirus Disease 2019 (COVID-19) admitted to intensive care units (ICU) or wards from the ED.</p> <p><strong>Methods</strong>: A retrospective data analysis of patients who were admitted to Ankara City Hospital ICUs and wards with the diagnosis of COVID-19 was performed. Group 1 included patients admitted to ICUs and Group 2 included those admitted to wards.</p> <p><strong>Results:</strong> A total of 127 patients were admitted with a COVID-19 diagnosis. Mean age in Group 1 and Group 2 were 46±17 and 41±14, respectively. The number of patients admitted to ICU (Group 1) was 46 (36.2%), and the number of patients admitted to wards (Group 2) was 81 (63.7%). Of all patients, 122 patients (96.06%) were discharged and 5 patients (3.9%) died. RDW values in Group 1 was higher than those in Group 2 (p&lt;0,001). Similarly, MPV was higher in Group 1 than Group 2 (p&lt;0,001).</p> <p><strong>Conclusion:</strong> In patients with COVID-19, RDW and MPV values are higher in those admitted to ICU than patients admitted to wards from the ED.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Factors Affecting the Nutritional Habits of Cerebral Palsy Patients 2021-04-09T12:30:03+00:00 Merve Çalkın Korkmaz Mehmet Ağırman Elif Ay <p><strong>Background:</strong> Cerebral palsy (CP) is a motor control and postural disorder. Feeding problems in children with CP increase the risk of morbidity and mortality by leading to malnutrition and growth retardation. In this study, we aimed to investigate the factors affecting the dietary habits of patients with CP.</p> <p><strong>Methods</strong>: Patients with CP who participated in the rehabilitation program in Medipol University Department of Physical Medicine and Rehabilitation were included in the study. The dietary habits of the patients were evaluated and biceps, triceps, and subscapular skin thickness, mid-upper arm circumference was measured. Beck depression inventory (BDI) was filled in by all mothers. The study included 29 patients with CP (16 males and 13 females with a mean age of 3.9 ± 3.1).</p> <p><strong>Results:</strong> No correlations were found between biceps, triceps and subscapular skin thickness, mid-upper arm circumference, maternal depression level, and eating habits. There were statistically significant correlations between the gross motor functional classification system (GMFCS) and saliva (r:0.396, p:0.008), reflux (r:0.142, p:0.046), constipation (r:0.361, p:0.044), gas presence (r:0.483, p:0.008), and mid-upper arm circumference (r:0.483, p:0.008).</p> <p><strong>Conclusion:</strong> These results indicate that nutritional problems increase as the level of functional disability increases.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Investigation of the Effect of Pentoxifylline and Tocopherol on Osseous Healing Following Tooth Extraction in Bisphosphonate-Administered Rats 2021-05-05T11:44:56+00:00 Ezgi Tuncay Mustafa Öztürk Ayşenur Tanıdır Burcu Şengüven burcu.sengü Özge Paşaoğlu <p><strong>Background:</strong> The incidence of medication-related osteonecrosis of the jaw has increased with the widespread use of bisphosphonates. Present study aimed to evaluate the effect of pentoxifylline and/or tocopherol alone or in combination, on bisphosphonate-induced osteonecrosis in tooth extracted rat jaw.</p> <p><strong>Methods:</strong> 24 rats were randomly assigned to 4 groups and each animal received intraperitoneal zoledronic acid injection 0.06 mg/ kg/week for 3 weeks. Following the zoledronic acid application, the lower right first molars of the rats were extracted on day 22. Starting from the day of tooth extraction animals received intraperitoneal pentoxifylline and/or tocopherol injections. Fourteen days later all rats were sacrificed. RANKL and osteoprotegerin (OPG) in blood were measured, and mandibles were examined histologically. When the inter-group differences were evaluated, the Kruskal Wallis-H Test and the Chi-square analysis were used.</p> <p><strong>Results:</strong> Each groups’ serum RANKL, OPG and RANKL/OPG levels did not reveal any statistically significant differences. There were no statistically significant differences in terms of bone necrosis, abscess formation, inflammation, osteoblastic/osteoclastic activity, bone cellularity and epithelial integrity.<br />Conclusions: Pentoxifylline and/or tocopherol injections alone or in combination did not have any statistically significant effect<br />on the jaw following tooth extraction in bisphosphonate-induced rat animal model.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research The Influence of Body Mass Index on Lower Extremity Vein Diameters at Different Levels in Healthy Population 2021-04-15T05:51:00+00:00 Işıl Yıldız Demet Gündüz <p><strong>Background:</strong> To investigate changes in the size of the deep and superficial venous systems associated with body mass index (BMI), gender, age, in patients without venous insufficiency including the effects of posture.</p> <p><strong>Methods:</strong> Healthy individuals who had no previous diagnosis of venous insufficiency were evaluated with an ultrasound device with a duplex option. The left and right deep and superficial venous systems were scanned both supine and upright positions by the same two radiologists. All clinical findings, BMI and age were recorded for each subject.</p> <p><strong>Results:</strong> Two-hundred ninety-eight patients were included in the study. The patients’ mean age and BMI were 49.94 ±13.19 years (range 19-76), BMI was 24.91±4.0 kg/m² (range 18-38) respectively. The difference between upright and supine positions vein diameters were statistically significant (p&lt;0.01). There were no significant differences between overweight and normal participants in terms of femoral and saphenous vein diameters (p&gt;0.05). The proximal diameter of the great saphenous vein was significantly lower in overweight patients (Table 2). When the patients were analyzed according to BMIs the right femoral vein diameters, the diameters of proximal part and distal two parts of the right great saphenous vein, and left proximal small saphenous vein diameters were significantly higher in patients whose BMI values were between 35-39.99 (obese-class II) (p&lt;0.001).</p> <p><strong>Conclusions:</strong> In conclusion we found both lower limbs’ vein diameters were significantly larger in upright position either superficial and deep systems, however the relationship between age and BMI was not significant. Further longitudinal studies are needed to clarify the influence of anatomic variances in subjects with obese healthy veins.</p> <p><strong> </strong></p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Comparison of Suture-Button Versus Hook- Plate Fixation for Acromioclavicular Joint Injuries 2021-04-25T21:10:24+00:00 Osman Yağız Atlı Hüseyin Bilgehan Çevik Hakan Aslan Evrim Duman <p><strong>Background:</strong> This retrospective study aimed to compare the clinical and radiological results of clavicular hook plate fixation versus suture-button fixation of acromioclavicular joint (ACJ) dislocations.</p> <p><strong>Methods:</strong> 21 patients are retrospectively evaluated in the present study whom diagnosed as type III-V ACJ dislocations and treated by two different surgical methods. The hook plate group comprised 9 patients to whom acromioclavicular fixation. The suture-button group comprised 12 patients to whom coracoclavicular fixation. All patients were evaluated by Constant Murley Score (CMS) and visual analogue score (VAS). Loss of reduction and radiological results were evaluated with the coracoclavicular distance (CCD).</p> <p><strong>Results:</strong> The average follow-up was 31 months (range, 15–56 months). There was no significant difference between hook-plate and suture-button groups in terms of CMS. However, VAS in hook plate group better than suture-button group (p = 0.038). Suturebutton fixation adjusted the CCD more than hook plate fixation compared to the opposite shoulder (p = 0.482).</p> <p><strong>Conclusions:</strong> There was no statistically significant difference between the hook plate and suture-button group in terms of the clinical outcomes. However, CCD in the suture-button group was better adjusted to the hook plate group. Suture-button fixation is a good option for the treatment of ACJ dislocations, as implant removal may be required in most cases in which the hook plate is applied.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Clinical and Functional Outcomes of Using Double-Row Transosseous Fixation Material in Advanced Age Treatment of Rotator Cuff Tears 2021-04-14T08:27:17+00:00 Mehmet Cenk TURGUT Serdar Toy Mehmet KÖSE Muhammed Çağatay Engin <p><strong>Background:</strong> Rotator cuff tears are the most common cause of shoulder pain in the elderly. Various techniques have been used in the treatment of rotator cuff tears. This study discusses the clinical and functional outcomes in patients in whom rotator cuff tears have been repaired using double-row transosseous fixation material.</p> <p><strong>Methods:</strong> The study is carried out on 37 elderly patients who underwent mini-open arthroscopy-supported transosseous repair between February 2017 - March 2019. Age and gender of the patients as well as the tear development mechanism, tear grade, fatty degeneration grade, acromion type, and the University of California - Los Angeles (UCLA) Shoulder Scale and Constant-Murley functional and clinical scores (CMS) before and six months after the surgery were recorded.</p> <p><strong>Results:</strong> Mean patient age was 61.19±6.74 (range: 52-76). 17 (45.9%) were female, and 20 (54.1%) were male. The mean preoperative CMS score was 37.68±8.64, and the mean UCLA score was 14.19±8.64. Mean postoperative CMS and UCLA scores were 76.84±9.57 and 28.14±3.02, respectively. Preoperative and postoperative CMS and UCLA scores were statistically significantly different (p&lt;0.001).</p> <p><strong>Conclusions:</strong> Arthroscopy-aided transosseous method using Sharc-FT instrument both prevents open surgery complications and results in lower infection rates and less muscular power loss. Considering both its functional and clinical outcomes, Sharc-FT is a utilizable instrument.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Skin Findings Related with COVID-19, Review of the Current Literature 2021-04-07T20:26:38+00:00 Sezin Ünlü Açıkel Akın Aktaş <p>COVID-19 is an acute respiratory infection that is caused by SARS-coV2 and it was declared a pandemic by the World Health Organization in March 2020. Many different skin manifestations such as urticarial lesions, maculovesicular lesions, papulovesicular lesions, MIS-C lesions, purpuric / petechial lesions, livedoid lesions, and thrombotic-ischemic lesions have been described in this infection. Thus, timely and accurate identification of skin findings might be beneficial in terms of early diagnosis. In addition, the type of lesion gives information about prognosis in some cases. The exact mechanism for the formation of skin lesions is not known, but the immune system activation, the direct cytopathic effect of the virus, the microvascular damage, hypercoagulopathy and complement activation are factors that are thought to play a role in the pathogenesis. Further studies are required in order to systematize the skin findings seen in COVID-19 and to reveal their mechanisms. Furthermore, the COVID-19 pandemic has also induced various skin complications such as pressure sores, dry skin, dermatitis, and contact urticaria due to the use of personal protective equipment (PPE). Besides, the use of PPE might cause exacerbation of skin diseases such as acne, rosacea, seborrheic dermatitis, atopic dermatitis.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Renal Epithelioid Angiomyolipoma with Aggresive Progression: A Case Report and Literature Review 2021-04-21T08:10:03+00:00 Emre Altıntaş Ali Furkan Batur Mehmet Kaynar Murat Gül Murat Akand Serdar Göktaş Zeliha Esin Çelik Özcan Kılıç <p>Epithelioid cellular morphology can be seen in clinically benign usual (or classic) angiomyolipoma (AML). Perivascular Epithelioid Cell Tumors (PEComa) are rarely seen as a variant of AML and usually benign in nature; however, they may have unpredictable pathological behavior. Here, we present a case of renal PEComa with malignant clinical progression and compare it with the current literature. A 56-year-old patient with a history of recurrent side pain present for about four months applied to our clinic. A hypodense mass was detected on the upper pole of the left kidney by ultrasonography. Computerized tomography showed an 8x4 cm mass originating from the upper pole of the left kidney and the adrenal gland, and was thought to invade the psoas muscle. The patient underwent a left transperitoneal radical nephrectomy. During the operation, vena cava inferior repair was required due to invasion and performed. Histopathologic examination revealed a PEComa. During the third month follow-up visit, a recurrent mass and lymph node enlargement were detected at the operation site. The mass was excised, and histopathology revealed a PEComa again. Considered as a rare variant of AML, PEComa is a tumor with the potential to exhibit malignant behavior. Although only a limited number of cases of renal PEComa have been reported; diagnosis, treatment, and follow-up are important due to their high potential for malignancy.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research Unexpected Arrhythmia in a Young Patient: Hookah Smoking Triggered Atrial Fibrillation 2021-03-22T20:11:35+00:00 Muhammed Keskin Tufan Çınar Murat Selçuk Selami Doğan Vedat Çiçek Ahmet Lutfullah Orhan <p>In the current literature, although it has been known that hookah smoking increases the heart rate and predisposes to arrhythmia, no case report has been published regarding hookah smoking and the development of arrhythmia, including atrial fibrillation (AF). In this case report, we presented an adult patient without known cardiovascular disease who experienced AF after a heavy hookah smoking session. Following IV amiodarone infusion, normal sinus rhythm was achieved. The patient was advised to stop hookah smoking and discharged with a beta-blocker therapy and an oral anticoagulant treatment for 3 weeks. The patient’s rhythm was normal at one-month outpatient visit. This case emphasizes that hookah smoking could not be considered as a less harmful alternative to cigarette smoking because of its’ apparent side effects to the cardiovascular system.</p> 2021-05-29T00:00:00+00:00 Copyright (c) 2021 Archives of Current Medical Research